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BindCraft2: De Novo Protein Binder Design, Open-Sourced Ahead of the Paper

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BindCraft2 is an open-source suite for de novo protein binder design. Give it a target protein and pick a binder modality (miniprotein, cyclic peptide, VHH, scaffolded) and it returns candidate sequences, optimising through AlphaFold 2 with ProteinMPNN redesign and ranking them by structural filters. Released ahead of the paper, free for academic and industry use, runnable on a single GPU.

Protein DesignBindCraft2AlphaFoldProteinMPNNDrug DiscoveryOpen SourceBioAI
Category: research
Author: @tspy
Date: 2026-09-21T00:00:00
Duration: 11.32s
Source: https://x.com/tspy/status/2102037790519361557
Reference: https://github.com/PacesaLab/BindCraft2

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